I use Gnome on ~amd64 and everything is working fine.
I don't use pulse audio, just alsa.

I also had those issues with x11-drivers/nvidia-drivers-180.35 as Paul said.
Other than that I can't think of something right now.
Are all packages well? `revdep-rebuild` returns no problems ?


2009/5/1 Paul Hartman <paul.hartman+gentoo@gmail.com>
On Fri, May 1, 2009 at 2:51 PM, walt <w41ter@gmail.com> wrote:
> I'm asking because gnome is working perfectly on my ~x86 machine
> but not on my ~amd64.
>
> The problem is that gnome-settings-daemon and pulse audio are
> crashing during startup, i.e. they appear as defunct processes
> once gnome is up and running.
>
> It's a bit like the bug a few months ago where the "gnome-settings-
> daemon restarted too many times" error message popped up, but this
> time there are no error messages anywhere.
>
> Another odd thing is that I can't use Ctrl-C to kill any processes
> that I start from an xterm.
>
> Anyone else having similar problems?
>
> Thanks.

I had the same problem. In my case it was caused by
x11-drivers/nvidia-drivers-180.35  and changing to a different version
fixed it. Maybe you should check to see if you are using this version,
or try a different version (older/newer)... if you're not using
nvidia-drviers at all, then I have no idea what to say except "good
luck" :)