Currently gnome profiles enable automatically "gtk" USE flag and, then, most gtk based GUIs are installed by default on systems using that profile. A special situation occurs when the package is based in wxGTK as explained in: https://bugs.gentoo.org/show_bug.cgi?id=411053 Currently, packages like mkvtoolnix simply builds without no gui at all when using gnome profile because its gui is build with "wxwidgets" USE flag. At first, I suggested to move from wxwidgets to "gtk" USE flag for that package because that wxwidgets based gui is the only gtk gui offered by that package. The problem is that their maintainers disagree with that approach as explained in referred bug report. Other option would be to enable "wxwidgets" by default for that profiles. What do you think?